Intermediate Filament Details

INTEGRATED SEQUENCE VIEW

Information last updated on 2009-07-21 17:00:09 * variant associated with disease as a risk factor rather than a causal factor. Note: Sequences are numbered according to latest reference sequence information. Discrepancies may exist with some publications. Chromosome 10p13 Chromosome Strand + Chromosome GI 51511726 Chromosome RefSeq ID NC_000010.8 17311304 : GTCCCCGCGC CAGAGACGCA GCCGCGCTCC CACCACCCAC ACCCACCGCG : 17311353 -124 : GTCCCCGCGC CAGAGACGCA GCCGCGCTCC CACCACCCAC ACCCACCGCG : -75 17311354 : CCCTCGTTCG CCTCTTCTCC GGGAGCCAGT CCGCGCCACC GCCGCCGCCC : 17311403 -74 : CCCTCGTTCG CCTCTTCTCC GGGAGCCAGT CCGCGCCACC GCCGCCGCCC : -25 17311404 : AGGCCATCGC CACCCTCCGC AGCCATGTCC ACCAGGTCCG TGTCCTCGTC : 17311453 -24 : AGGCCATCGC CACCCTCCGC AGCCATGTCC ACCAGGTCCG TGTCCTCGTC : 26 1 : M S T R S V S S S : 9 17311454 : CTCCTACCGC AGGATGTTCG GCGGCCCGGG CACCGCGAGC CGGCCGAGCT : 17311503 27 : CTCCTACCGC AGGATGTTCG GCGGCCCGGG CACCGCGAGC CGGCCGAGCT : 76 10 : S Y R R M F G G P G T A S R P S : 25 17311504 : CCAGCCGGAG CTACGTGACT ACGTCCACCC GCACCTACAG CCTGGGCAGC : 17311553 77 : CCAGCCGGAG CTACGTGACT ACGTCCACCC GCACCTACAG CCTGGGCAGC : 126 26 : S S R S Y V T T S T R T Y S L G S : 42 17311554 : GCGCTGCGCC CCAGCACCAG CCGCAGCCTC TACGCCTCGT CCCCGGGCGG : 17311603 127 : GCGCTGCGCC CCAGCACCAG CCGCAGCCTC TACGCCTCGT CCCCGGGCGG : 176 43 : A L R P S T S R S L Y A S S P G G : 59 17311604 : CGTGTATGCC ACGCGCTCCT CTGCCGTGCG CCTGCGGAGC AGCGTGCCCG : 17311653 177 : CGTGTATGCC ACGCGCTCCT CTGCCGTGCG CCTGCGGAGC AGCGTGCCCG : 226 60 : V Y A T R S S A V R L R S S V P : 75 17311654 : GGGTGCGGCT CCTGCAGGAC TCGGTGGACT TCTCGCTGGC CGACGCCATC : 17311703 227 : GGGTGCGGCT CCTGCAGGAC TCGGTGGACT TCTCGCTGGC CGACGCCATC : 276 76 : G V R L L Q D S V D F S L A D A I : 92 17311704 : AACACCGAGT TCAAGAACAC CCGCACCAAC GAGAAGGTGG AGCTGCAGGA : 17311753 277 : AACACCGAGT TCAAGAACAC CCGCACCAAC GAGAAGGTGG AGCTGCAGGA : 326 93 : N T E F K N T R T N E K V E L Q E : 109 17311754 : GCTGAATGAC CGCTTCGCCA ACTACATCGA CAAGGTGCGC TTCCTGGAGC : 17311803 327 : GCTGAATGAC CGCTTCGCCA ACTACATCGA CAAGGTGCGC TTCCTGGAGC : 376 110 : L N D R F A N Y I D K V R F L E : 125 17311804 : AGCAGAATAA GATCCTGCTG GCCGAGCTCG AGCAGCTCAA GGGCCAAGGC : 17311853 377 : AGCAGAATAA GATCCTGCTG GCCGAGCTCG AGCAGCTCAA GGGCCAAGGC : 426 126 : Q Q N K I L L A E L E Q L K G Q G : 142 VARIANTS : A : VARIANTS 17311854 : AAGTCGCGCC TGGGGGACCT CTACGAGGAG GAGATGCGGG AGCTGCGCCG : 17311903 427 : AAGTCGCGCC TGGGGGACCT CTACGAGGAG GAGATGCGGG AGCTGCGCCG : 476 143 : K S R L G D L Y E E E M R E L R R : 159 VARIANTS : K : VARIANTS 17311904 : GCAGGTGGAC CAGCTAACCA ACGACAAAGC CCGCGTCGAG GTGGAGCGCG : 17311953 477 : GCAGGTGGAC CAGCTAACCA ACGACAAAGC CCGCGTCGAG GTGGAGCGCG : 526 160 : Q V D Q L T N D K A R V E V E R : 175 17311954 : ACAACCTGGC CGAGGACATC ATGCGCCTCC GGGAGAAGTA AGGCTGCGCC : 17312003 527 : ACAACCTGGC CGAGGACATC ATGCGCCTCC GGGAGAA : 563 176 : D N L A E D I M R L R E K : 188 17312004 : CATGCAAGTA GCTGGGCCTC GGGAGGGGGC TGGAGGGAGA GGGGAACGCC : 17312053 17312054 : CCCCCGGCCC CCGCGAGAGC TGCCACGCCC TTGGGGATGT GGCCGGGGGG : 17312103 17312104 : AGGCCTGCCA GGGAGACAGC GGAGAGCGGG GCTGTGGCTG TGGTGGCGCA : 17312153 17312154 : GCCCCGCCCA GAACCCAGAC CTTGCAGTTC GCATTTCCTC CTCTGTCCCC : 17312203 17312204 : ACACATTGCC CAAGGACGCT CCGTTTCAAG TTACAGATTT CTTAAAACTA : 17312253 17312254 : CCACTTTGTG TGCAGTTGAA GGCCCTTGGG CACAATGAGA GCCAGTCCTC : 17312303 17312304 : CAAACTTTCA GAAAGTTTCC TGCCCCTTCT GGCAGGCTGC CAATCACCGG : 17312353 17312354 : GCGGGAGAAG GAAGGAGGGG AAGGCGGTGG AGGGAGCGAG ACAAAGGGAT : 17312403 17312404 : GGTCCCTCGG GGGCGGGGAT GGCGGGGCTG TCCTGTAGGT CTGTGCGGCC : 17312453 17312454 : ACCGTGATTG CCCCTCTGCG CGGTGCCCGA AGTCCCGCTG AAACCTGCCG : 17312503 17312504 : AGGGCAGCAG GTCTGAAAGC TGCAGGCGCT AGTTGCGCGG AGGTGGCGCA : 17312553 17312554 : GCTGCTCTGG AGGCGCAGAG CGAATACGTG GTGTTTGGGT GTGGCCGCCC : 17312603 17312604 : CGCCCCTGGC GGTTTCCTCG TTCCCCTTTG GTTAATGCGC AACTGTTTCA : 17312653 17312654 : GATTGCAGGA GGAGATGCTT CAGAGAGAGG AAGCCGAAAA CACCCTGCAA : 17312703 564 : ATTGCAGGA GGAGATGCTT CAGAGAGAGG AAGCCGAAAA CACCCTGCAA : 612 189 : L Q E E M L Q R E E A E N T L Q : 204 17312704 : TCTTTCAGAC AGGTTTGTAG ACTCTCTTCC CACTCGCAGC CGCCTGACCC : 17312753 613 : TCTTTCAGAC AG : 624 205 : S F R Q : 208 17312754 : CACCCAACAC AACCCACGAG CAATTCTAAA AGTTGCTTAA CTCACGTCTA : 17312803 17312804 : AAAAGTGCAA AACTTCAGGG CTGCGCGTAA AGCCCTCTAG TGGCGGGAAG : 17312853 17312854 : ACCACAGGTT GGAGCTTCTC ATGATTAGAA AAATATTAAT AAAACCCCTT : 17312903 17312904 : GAGCGATTTT TTTTTTTTTT TTGAGACGGA GTCTTACTCT GTCGCCCAGG : 17312953 17312954 : CTGGAGTGCA GTGGCGAGAT CTTGGCTCAC TGCATCCTCC GCCTCCCGGG : 17313003 17313004 : TTCAAGCGAT CCTTGAATGA TTTCTAAGCA GTTCCTTGGG ACATAAAGAA : 17313053 17313054 : AAATCTTTTA ACTTTTTACT TTGTTTCCCA AATGTTGCAC AGTTTTGCAA : 17313103 17313104 : CACATTGACC TTCTGGTTTC GAACGGTTAC AATTTTAGAT TGTGGTTTGC : 17313153 17313154 : CAAAGTCAAG TTGCTTAATT TTTACAAGGC CACAAAAAGC GCAATTATGC : 17313203 17313204 : CCTGCAGTTT AAAATGGAAA ACGTGTTGGA AGATAAGAAA ACTTAGTTTC : 17313253 17313254 : CAACTGGAAT GGAGCCAGCA AGTTTCTTTT CTTCTTTGCA AATTCTATTG : 17313303 17313304 : TGTCATTAAA GTTCGATGGA AGTATCACTA TGCACAACTA TTTTGTGATC : 17313353 17313354 : TAATAAGGGT GAAAAGGAGC CATCTGTCCC CTTGGCTAAG GGGTATTAAT : 17313403 17313404 : GGTTTCTATG GGCTTCACTA TGGAATGTAG ATACAGACAT TCTGGCAAAT : 17313453 17313454 : GTGGTGGCTC TGGACAGAAA TAATAGGAGT CTTTGTATTC CCAGGGAAGC : 17313503 17313504 : TTTGCAACAG GCTACATTCT TACTGAATAT GTAATGATGT AAGCACGGTT : 17313553 17313554 : CTAATTGGAC ACAAGTATTT GCTAACATCC GTTATCTAAT ATCTGGCCCA : 17313603 17313604 : GACTTGAGAA GTAGGTAATG TAAAAAGTTT TTAAAGCTAC AAGCATACCT : 17313653 17313654 : CACATTTTAA AAGTCCTTTC TTGATTGGGT TCTTGTGTTC TTTAGCACTC : 17313703 17313704 : TTGCCATAAA AAATAATAAC AGTAATAAAC CCAAGGCTGA AAAACTGAAT : 17313753 17313754 : TTTAACTAAA GGGTTTTTGT GCGTGTTTTT TTTTTTTTTC ACCAAAATTA : 17313803 17313804 : GATGGACTTA CAGAATTTTT AACTTAAAAT TGGAATCCAA AAGCCAGAAG : 17313853 17313854 : ATCCCCATTA TAGTTTATAG TTGTATTCCC TGGAATATTT ACTGGGATTA : 17313903 17313904 : ACTGCAAAGC ACTCTCAGAT GAATAGTGTA GTATAACATT TTGAAACTGA : 17313953 17313954 : AATACATTTA CCAAATTAAT TTAACCACAG CAATGTGTGT GGTTCATTTT : 17314003 17314004 : AGTCCTTGAG CATTTTTGAT TATCATACCT GTCATGTTTT CTGCAGTGTA : 17314053 17314054 : GTGAGTTAAC ATAAAACAAC ATCAATACAA AAGATCCTCT GTTTCGAGAT : 17314103 17314104 : TAAGCAAAAT TCCTCATTCT CTTCAATGTG ATAGAATACC ACATTGATCT : 17314153 17314154 : TTCTTTGGAG GTTAGTAAAA TATCTTTTAT GTATTTTTCA GGGCTTAACA : 17314203 17314204 : AGTAAAAATC AATGTTTTCA TCAAGTCTGA TCTTTTTGTC ACCCACTCTT : 17314253 17314254 : CATTCATTTT TCCACTAAGG TGATAGAAAA GTCTCAACAG TTTAAGACCG : 17314303 17314304 : TAAGGCTATG AACTCCAAAT ATAATTGCTG ACAAGATAAG CAATCCTCAC : 17314353 17314354 : GCATCCTTTT GAGAGGAAAT AAAATCTTAG TTGCAAGATT ACATATTCTG : 17314403 17314404 : ATTTGGAATG CTGAGCTTTT TAAATGGAAA TATAGAAGGA CGGCTGAATC : 17314453 17314454 : AGCAAAAATC CTTTATGTAG TTTCATTCTT TGCAAGCTTG ACCAGTCATT : 17314503 17314504 : CTGAAACAGG CTAACTGAAC TGATACAGTG GCAAGTGAAA AAGACATGCC : 17314553 17314554 : TTTACAGGAT GAGTCAAAGG AGTTTTAGAA GAAAAATCCA CCAGAGAAAG : 17314603 17314604 : CCAAGCAAAT ACAGTTCAGA GTTACATTTC TTTTCCATTT TTTCCTGAAC : 17314653 17314654 : TGAATCTTTG GCATGCATAT CCTGAATTGG GTTATTGAAT ATAAATCTAG : 17314703 17314704 : CCTTGTACAA TGGATGCCAG ATGACTACAT ATTTGCTTTG GAGCCTAAGG : 17314753 17314754 : ATAAGTTTCA AAAGATTTGA GTGGAGAAGA AAAGCTAAAA CTCTTGAAGC : 17314803 17314804 : ACAAGTTTCT GTTCTCCATG TACTCAAGTG TACATGAAGT TGTGAAAATT : 17314853 17314854 : TGTCCACCTC TATCATCATG TTATTCCATG AAATTACAAA ACAAATCTTA : 17314903 17314904 : AAAATGTTGT GGCATAGATT TTCTAGATTT AAAAAGTAAT TAAATTAAAT : 17314953 17314954 : GAATTACTTT ATTTTTTGAG ACAGAGTGTC ACTCTGTTGC CCAGGCTGGA : 17315003 17315004 : GTGCAGTGGC ACTATGTTGG CTCACTGCAA CCTCTGCCTC CTGGGTTGAA : 17315053 17315054 : GAAATTCTCC TGCCTCAACC TCCCAAGTAG CTGGGACTAC AGGCATGTGC : 17315103 17315104 : CACCACACCC AGCTAATTTT TGTATTTTTG GTAGAGACGG GGTTTCGCCA : 17315153 17315154 : TGTTGGCTAG GCTGGTCTCG AACTCCTGAC CTCAAGTGAT CCACCCGTCT : 17315203 17315204 : CAGCCTCCCA AAGTGCTGGG ATTACAGGCA TAAGCCACCA TGACCAGCCT : 17315253 17315254 : TAAAAAGTAA TTTTAAAATA TCACTGGTAA AATGTGGATT CAGTCATGAT : 17315303 17315304 : TGAGTGCAGT TTACCATGTG TGTGGACATT TATTTATTTT AAAATTGTCT : 17315353 17315354 : GATCACCACC TTGAGTAAAA CACAAGCAGT CACAATTAAA ATATATTAGT : 17315403 17315404 : GAGCAGGAGA AAGCACAGCA TATTATAGCA CTGAATGATT TATAAACCTA : 17315453 17315454 : TTCCAGGGTC ATAAAATGTG TCAACGGCTT TTCTATAGTA AGGAGACTAG : 17315503 17315504 : GTTCAGATGG TTAATCTAAG ACAAATAAAT GAGATAAGCC ATACACTTTT : 17315553 17315554 : ACATCCTCCA TGTCCTGTCT TTTCTCTGTT CAAAATAGGA TGTTGACAAT : 17315603 625 : GA TGTTGACAAT : 636 209 : D V D N : 212 17315604 : GCGTCTCTGG CACGTCTTGA CCTTGAACGC AAAGTGGAAT CTTTGCAAGA : 17315653 637 : GCGTCTCTGG CACGTCTTGA CCTTGAACGC AAAGTGGAAT CTTTGCAAGA : 686 213 : A S L A R L D L E R K V E S L Q E : 229 17315654 : AGAGATTGCC TTTTTGAAGA AACTCCACGA AGAGGTTAGT GGAGTGACTT : 17315703 687 : AGAGATTGCC TTTTTGAAGA AACTCCACGA AGAG : 720 230 : E I A F L K K L H E E : 240 17315704 : TCGGGGAATG AATGAGGGTA AGGCAGCCCC CACGGTTGGC AGAGCTGACC : 17315753 17315754 : GTCTGTCTGT TCTTTTTGCA GGAAATCCAG GAGCTGCAGG CTCAGATTCA : 17315803 721 : GAAATCCAG GAGCTGCAGG CTCAGATTCA : 749 241 : E I Q E L Q A Q I Q : 250 17315804 : GGAACAGCAT GTCCAAATCG ATGTGGATGT TTCCAAGCCT GACCTCACGG : 17315853 750 : GGAACAGCAT GTCCAAATCG ATGTGGATGT TTCCAAGCCT GACCTCACGG : 799 251 : E Q H V Q I D V D V S K P D L T : 266 17315854 : CTGCCCTGCG TGACGTACGT CAGCAATATG AAAGTGTGGC TGCCAAGAAC : 17315903 800 : CTGCCCTGCG TGACGTACGT CAGCAATATG AAAGTGTGGC TGCCAAGAAC : 849 267 : A A L R D V R Q Q Y E S V A A K N : 283 17315904 : CTGCAGGAGG CAGAAGAATG GTACAAATCC AAGGTAGGAA ACAAATCAGT : 17315953 850 : CTGCAGGAGG CAGAAGAATG GTACAAATCC AAG : 882 284 : L Q E A E E W Y K S K : 294 17315954 : GCGGCTTCAA CCAAAGAAAA GCATTGTGTT CTCAAAACCC CATACCTGTG : 17316003 17316004 : TGTGATTCCT AAATATCCTC TAGCTCCAAT GCAAAGCTGG CTTTGACTTC : 17316053 17316054 : TTGCTCATAT TGTGTTTGCC ACCACAGCCT CCCCACCACT CACATCACCT : 17316103 17316104 : CCTTTATTTA TTTATTTATT TTCTTATTTA TTTATGAGAC AGAGTCTTGC : 17316153 17316154 : TCTACTGCCC AGGCTGGAGT GCAGTGGCAA CATCTTGGCA CACTGCAACC : 17316203 17316204 : TCCGCCTCCC AGGTTCAAGT GATTCTCCTG CCTCAGCCCC CTAAGAGCTG : 17316253 17316254 : GAACCACAGG CAAGCACCAC CATGCCCGGC TAATTTTTGT ATTTTTAGTA : 17316303 17316304 : GAGATGGGGT TTCACCATGT TGACCAGGCT TCTCTCAAAC TCCTGACCTC : 17316353 17316354 : AGGTGATCCA CCCTCCTCAG CCTCCCAAAA TGTTGGGATT ACAGGCATGC : 17316403 17316404 : GCCACCACGC CTGGCCACAT CACCTCCTTC AGAATAGCAG ACTCTCTTCC : 17316453 17316454 : CCCTAACCTT GCCTCCAAGT AAACCCCAAT GCCATACCTT TGACCTCCAC : 17316503 17316504 : TGTGTTGAAA TGAGCACTGT AGAGTGAACT CTGAAAATAC TAATGTCAGT : 17316553 17316554 : ACTCCACTGC TCTTTCCCTG GCTTTCAAAA CAGAAATTTA AACCTATACT : 17316603 17316604 : GGAAGACATT CAGTGAGAAA TATGATTTTT TTTTTCTAAG AGAGTCAAAA : 17316653 17316654 : GACTTGAATG TGAGCAATCT ACATTTCTGT TTTCTTCCCA ACAGTTTGCT : 17316703 883 : TTTGCT : 888 295 : F A : 296 17316704 : GACCTCTCTG AGGCTGCCAA CCGGAACAAT GACGCCCTGC GCCAGGCAAA : 17316753 889 : GACCTCTCTG AGGCTGCCAA CCGGAACAAT GACGCCCTGC GCCAGGCAAA : 938 297 : D L S E A A N R N N D A L R Q A K : 313 17316754 : GCAGGAGTCC ACTGAGTACC GGAGACAGGT GCAGTCCCTC ACCTGTGAAG : 17316803 939 : GCAGGAGTCC ACTGAGTACC GGAGACAGGT GCAGTCCCTC ACCTGTGAAG : 988 314 : Q E S T E Y R R Q V Q S L T C E : 329 17316804 : TGGATGCCCT TAAAGGAACC GTGAGTACCA ACCCTGCAGT AAAAGAGGGA : 17316853 989 : TGGATGCCCT TAAAGGAACC : 1008 330 : V D A L K G T : 336 17316854 : AAATAATGAC CCATTCTGCT GACTAGGCTC ATGATGATAC CTGAACAAAA : 17316903 17316904 : TGTTGAGTGA GTAAAAATGT ATATCATAAT GCAAAGAAAA TGAGTTATCA : 17316953 17316954 : AGACAGACTC AAAAGGGACT TCATGGAACT CTTGAAGGTT TTAGCTTGCC : 17317003 17317004 : TATATCATTG CTTCTAATAT GAAGGACTTG GTACTCGCAT TCTCCACCTA : 17317053 17317054 : AAATTAGAGT GGTCGCCATT TGCCGCTAAT GGAAATTATT GCAGAAGGTC : 17317103 17317104 : TGTAAATGGT TCTGGGAACA GCTGGGTTTT TCTGAGAAAT AACACCAGAC : 17317153 17317154 : ATCTTTCTCA CCCCCTGCAG AATGAGTCCC TGGAACGCCA GATGCGTGAA : 17317203 1009 : AATGAGTCCC TGGAACGCCA GATGCGTGAA : 1038 337 : N E S L E R Q M R E : 346 17317204 : ATGGAAGAGA ACTTTGCCGT TGAAGCTGCT AACTACCAAG ACACTATTGG : 17317253 1039 : ATGGAAGAGA ACTTTGCCGT TGAAGCTGCT AACTACCAAG ACACTATTGG : 1088 347 : M E E N F A V E A A N Y Q D T I G : 363 17317254 : CCGCCTGCAG GATGAGATTC AGAATATGAA GGAGGAAATG GCTCGTCACC : 17317303 1089 : CCGCCTGCAG GATGAGATTC AGAATATGAA GGAGGAAATG GCTCGTCACC : 1138 364 : R L Q D E I Q N M K E E M A R H : 379 17317304 : TTCGTGAATA CCAAGACCTG CTCAATGTTA AGATGGCCCT TGACATTGAG : 17317353 1139 : TTCGTGAATA CCAAGACCTG CTCAATGTTA AGATGGCCCT TGACATTGAG : 1188 380 : L R E Y Q D L L N V K M A L D I E : 396 17317354 : ATTGCCACCT ACAGGAAGCT GCTGGAAGGC GAGGAGAGCA GGTAGGGAAC : 17317403 1189 : ATTGCCACCT ACAGGAAGCT GCTGGAAGGC GAGGAGAGCA G : 1229 397 : I A T Y R K L L E G E E S R : 410 17317404 : TCAGACTTGG ATGCGTGAAC TAATGGTGAC CATTTGTTAG GCCCTGTGCC : 17317453 17317454 : ACTGGGCTCT AAGCAGTGTC ACATTTAATC TTTAGAAAGT TTCTTTGAGG : 17317503 17317504 : TAACTGCTTT CCACTTTTTG TAGAGGAGGA ATTTGAATTG AGAGAGAGTA : 17317553 17317554 : AGTGACTTGC TGAAAAAGGG TTAATCAACA GCAGAGCTGG GATTTGAACC : 17317603 17317604 : CATAACTCTG TCAAAGCCTC CACTCCTAAC TCCTGTTCAT GCTCCTGTGG : 17317653 17317654 : AGAAAATGCT TGTAGTAACA TATTTTAAAT GTACTAACAA GACCAGTCAT : 17317703 17317704 : GGGAAAATGT TTCTGAGACA AATCTCTAGT TTATGATTTA AAACAGTACG : 17317753 17317754 : TTTTCTTACG TGACGAAAAC AAAAAGTGTG TTAATTTGTT CCCAGTGGTT : 17317803 17317804 : GAAGTTATTT GCCAACAATT TTACTGTTTC TCTTCATCTG TTTATAGGAT : 17317853 1230 : GAT : 1232 411 : I : 411 17317854 : TTCTCTGCCT CTTCCAAACT TTTCCTCCCT GAACCTGAGG GGTAAGCATT : 17317903 1233 : TTCTCTGCCT CTTCCAAACT TTTCCTCCCT GAACCTGAGG G : 1273 412 : S L P L P N F S S L N L R : 424 17317904 : TTATTTCCCT TTAGGAAAAA CGTCAGCTGC TTGTAACCAC TGTGTTTATG : 17317953 17317954 : TCAAAGCATT CATTTTTTTT AGGATATCTG AAAAAATGCC ATATAAGAGA : 17318003 17318004 : AAACTCTATA AAACATCTAT AATTTTCGAA CCCAAGTACA CTCTTGCATT : 17318053 17318054 : CTATGCTTTA AGTTAAATGC AAACTCCTTT TTCCTTCTTC CTGCTGCAAG : 17318103 17318104 : TACTATCTCA TCCTGATGCT CAAGAGTGTC AGGGCCTGGG TTTCCAAACA : 17318153 17318154 : GAGACTACCC TAAAATTATT TGGCGAGTAG TACTTTACAC AATTGCCTCT : 17318203 17318204 : CCCCCACAAA TCATAATTGT TTCAGTAAAA TGGTTACTTG GTTTTTCCAA : 17318253 17318254 : GAAAAAACTC GTTTTTACTC ATTTTTGGCC TGTTTGTTTA TTTAGAAACT : 17318303 1274 : AAACT : 1278 425 : E T : 426 17318304 : AATCTGGATT CACTCCCTCT GGTTGATACC CACTCAAAAA GGACACTTCT : 17318353 1279 : AATCTGGATT CACTCCCTCT GGTTGATACC CACTCAAAAA GGACACTTCT : 1328 427 : N L D S L P L V D T H S K R T L L : 443 17318354 : GATTAAGACG GTTGAAACTA GAGATGGACA GGTTGGTATC TTTTAAGGAA : 17318403 1329 : GATTAAGACG GTTGAAACTA GAGATGGACA G : 1359 444 : I K T V E T R D G Q : 453 17318404 : AAAATAGGGT AATCTCAGAC AGGAGTTGAT ATATTTTAAA ATCAGTGAAT : 17318453 17318454 : CTGAATCTCA GATACAGCTG GCTAATTTGA GAGGTTCAGG TTTCATTCAT : 17318503 17318504 : GCCTACTAAA AAAAGAATAG GCTTCTTCTT CCAGCAGTAC ACACAGCCAA : 17318553 17318554 : CTAATTATTT GGCTCCTGGA TGTGAAGTTG AGATAGCAGT CTTCCTGTGC : 17318603 17318604 : TCCAGAATTA GTGATTTGCT TTGGTGCTTA ATTTGAAGTG GGAGTAAGCT : 17318653 17318654 : TCCTTAAACC ACTTCCTAAA GCAGCTACAT GAAACAGCTT CACTAGACTA : 17318703 17318704 : CCTCAATATG AGGAATGTTT TGATCCTGGA CATATGGTGT CTTCCTACCT : 17318753 17318754 : CCATACTTTA TAGATTCCTA AACCCATCTA TATAATACAA GCATGTGCCA : 17318803 17318804 : TACGATCATT TAGTTTCTTA TTACCTCCCT ATGCCAGGAA AGAAATAGTT : 17318853 17318854 : GCAATTTATT GTAGTCATCA TGAAATCTTC CCTTGCACAT AAATTTAAAA : 17318903 17318904 : TGTACCTGCT GCACATTTTA ATATGTCTTA ATTGCTTTTA AACTTGGCTG : 17318953 17318954 : TATTGTGTAC AACTATTATA CCATCTTTTA TAAACACAGT TTTTTAAGAA : 17319003 17319004 : ATTTCTTTTT GTAAGTTACA ACATTCCACT GGATCCTTAT ATTGCCTGTA : 17319053 17319054 : GTGGAAGAGG GTCTTGTGTG TCTGCCCCTT CTAGTTTTCA CTCATGCAGA : 17319103 17319104 : AGCAACATAA CCTTCTGATT TGCACAATAA ATTACATATA TTTAGCAGGA : 17319153 17319154 : TTTTTATTTG CCGTGATATA TAGGATAATT TAGTCTTTGG CATGTGGCAT : 17319203 17319204 : TATATTTATT TTGGTTTTTT TTTTTAAACA GGTTATCAAC GAAACTTCTC : 17319253 1360 : GTTATCAAC GAAACTTCTC : 1378 454 : V I N E T S : 459 17319254 : AGCATCACGA TGACCTTGAA TAAAAATTGC ACACACTCAG TGCAGCAATA : 17319303 1379 : AGCATCACGA TGACCTTGAA TAAAAATTGC ACACACTCAG TGCAGCAATA : *27 460 : Q H H D D L E : 466 17319304 : TATTACCAGC AAGAATAAAA AAGAAATCCA TATCTTAAAG AAACAGCTTT : 17319353 *28 : TATTACCAGC AAGAATAAAA AAGAAATCCA TATCTTAAAG AAACAGCTTT : *77 17319354 : CAAGTGCCTT TCTGCAGTTT TTCAGGAGCG CAAGATAGAT TTGGAATAGG : 17319403 *78 : CAAGTGCCTT TCTGCAGTTT TTCAGGAGCG CAAGATAGAT TTGGAATAGG : *127 17319404 : AATAAGCTCT AGTTCTTAAC AACCGACACT CCTACAAGAT TTAGAAAAAA : 17319453 *128 : AATAAGCTCT AGTTCTTAAC AACCGACACT CCTACAAGAT TTAGAAAAAA : *177 17319454 : GTTTACAACA TAATCTAGTT TACAGAAAAA TCTTGTGCTA GAATACTTTT : 17319503 *178 : GTTTACAACA TAATCTAGTT TACAGAAAAA TCTTGTGCTA GAATACTTTT : *227 17319504 : TAAAAGGTAT TTTGAATACC ATTAAAACTG CTTTTTTTTT TCCAGCAAGT : 17319553 *228 : TAAAAGGTAT TTTGAATACC ATTAAAACTG CTTTTTTTTT TCCAGCAAGT : *277 17319554 : ATCCAACCAA CTTGGTTCTG CTTCAATAAA TCTTTGGAAA AACTC : 17319598 *278 : ATCCAACCAA CTTGGTTCTG CTTCAATAAA TCTTTGGAAA AACTC : *322 Back to top

mRNA SEQUENCE

Reference sequence last updated on 2009-07-21 17:00:09 RefSeq ID NM_003380.2 GI 62414288 Length 1847 nucleotides Download File | Text Sequence Legend: Blue = CDS, Red = UTR -124 GTCCCCGCGC CAGAGACGCA GCCGCGCTCC CACCACCCAC ACCCACCGCG -75 -74 CCCTCGTTCG CCTCTTCTCC GGGAGCCAGT CCGCGCCACC GCCGCCGCCC -25 -24 AGGCCATCGC CACCCTCCGC AGCCATGTCC ACCAGGTCCG TGTCCTCGTC 26 27 CTCCTACCGC AGGATGTTCG GCGGCCCGGG CACCGCGAGC CGGCCGAGCT 76 77 CCAGCCGGAG CTACGTGACT ACGTCCACCC GCACCTACAG CCTGGGCAGC 126 127 GCGCTGCGCC CCAGCACCAG CCGCAGCCTC TACGCCTCGT CCCCGGGCGG 176 177 CGTGTATGCC ACGCGCTCCT CTGCCGTGCG CCTGCGGAGC AGCGTGCCCG 226 227 GGGTGCGGCT CCTGCAGGAC TCGGTGGACT TCTCGCTGGC CGACGCCATC 276 277 AACACCGAGT TCAAGAACAC CCGCACCAAC GAGAAGGTGG AGCTGCAGGA 326 327 GCTGAATGAC CGCTTCGCCA ACTACATCGA CAAGGTGCGC TTCCTGGAGC 376 377 AGCAGAATAA GATCCTGCTG GCCGAGCTCG AGCAGCTCAA GGGCCAAGGC 426 427 AAGTCGCGCC TGGGGGACCT CTACGAGGAG GAGATGCGGG AGCTGCGCCG 476 477 GCAGGTGGAC CAGCTAACCA ACGACAAAGC CCGCGTCGAG GTGGAGCGCG 526 527 ACAACCTGGC CGAGGACATC ATGCGCCTCC GGGAGAAATT GCAGGAGGAG 576 577 ATGCTTCAGA GAGAGGAAGC CGAAAACACC CTGCAATCTT TCAGACAGGA 626 627 TGTTGACAAT GCGTCTCTGG CACGTCTTGA CCTTGAACGC AAAGTGGAAT 676 677 CTTTGCAAGA AGAGATTGCC TTTTTGAAGA AACTCCACGA AGAGGAAATC 726 727 CAGGAGCTGC AGGCTCAGAT TCAGGAACAG CATGTCCAAA TCGATGTGGA 776 777 TGTTTCCAAG CCTGACCTCA CGGCTGCCCT GCGTGACGTA CGTCAGCAAT 826 827 ATGAAAGTGT GGCTGCCAAG AACCTGCAGG AGGCAGAAGA ATGGTACAAA 876 877 TCCAAGTTTG CTGACCTCTC TGAGGCTGCC AACCGGAACA ATGACGCCCT 926 927 GCGCCAGGCA AAGCAGGAGT CCACTGAGTA CCGGAGACAG GTGCAGTCCC 976 977 TCACCTGTGA AGTGGATGCC CTTAAAGGAA CCAATGAGTC CCTGGAACGC 1026 1027 CAGATGCGTG AAATGGAAGA GAACTTTGCC GTTGAAGCTG CTAACTACCA 1076 1077 AGACACTATT GGCCGCCTGC AGGATGAGAT TCAGAATATG AAGGAGGAAA 1126 1127 TGGCTCGTCA CCTTCGTGAA TACCAAGACC TGCTCAATGT TAAGATGGCC 1176 1177 CTTGACATTG AGATTGCCAC CTACAGGAAG CTGCTGGAAG GCGAGGAGAG 1226 1227 CAGGATTTCT CTGCCTCTTC CAAACTTTTC CTCCCTGAAC CTGAGGGAAA 1276 1277 CTAATCTGGA TTCACTCCCT CTGGTTGATA CCCACTCAAA AAGGACACTT 1326 1327 CTGATTAAGA CGGTTGAAAC TAGAGATGGA CAGGTTATCA ACGAAACTTC 1376 1377 TCAGCATCAC GATGACCTTG AATAAAAATT GCACACACTC AGTGCAGCAA *25 *26 TATATTACCA GCAAGAATAA AAAAGAAATC CATATCTTAA AGAAACAGCT *75 *76 TTCAAGTGCC TTTCTGCAGT TTTTCAGGAG CGCAAGATAG ATTTGGAATA *125 *126 GGAATAAGCT CTAGTTCTTA ACAACCGACA CTCCTACAAG ATTTAGAAAA *175 *176 AAGTTTACAA CATAATCTAG TTTACAGAAA AATCTTGTGC TAGAATACTT *225 *226 TTTAAAAGGT ATTTTGAATA CCATTAAAAC TGCTTTTTTT TTTCCAGCAA *275 *276 GTATCCAACC AACTTGGTTC TGCTTCAATA AATCTTTGGA AAAACTC Back to top

PROTEIN SEQUENCE AND DOMAIN INFORMATION

Reference sequence last updated on 2009-07-21 17:00:09 RefSeq ID NP_003371.2 GI 62414289 Isoelectric Point 4.7734 Molecular Weight 53651.5 Daltons Length 466 amino acids Download File | Text Sequence 1 MSTRSVSSSS YRRMFGGPGT ASRPSSSRSY VTTSTRTYSL GSALRPSTSR 50 51 SLYASSPGGV YATRSSAVRL RSSVPGVRLL QDSVDFSLAD AINTEFKNTR 100 101 TNEKVELQEL NDRFANYIDK VRFLEQQNKI LLAELEQLKG QGKSRLGDLY 150 151 EEEMRELRRQ VDQLTNDKAR VEVERDNLAE DIMRLREKLQ EEMLQREEAE 200 201 NTLQSFRQDV DNASLARLDL ERKVESLQEE IAFLKKLHEE EIQELQAQIQ 250 251 EQHVQIDVDV SKPDLTAALR DVRQQYESVA AKNLQEAEEW YKSKFADLSE 300 301 AANRNNDALR QAKQESTEYR RQVQSLTCEV DALKGTNESL ERQMREMEEN 350 351 FAVEAANYQD TIGRLQDEIQ NMKEEMARHL REYQDLLNVK MALDIEIATY 400 401 RKLLEGEESR ISLPLPNFSS LNLRETNLDS LPLVDTHSKR TLLIKTVETR 450 451 DGQVINETSQ HHDDLE Head  L1 L12 L2  Tail 1A 1B 2A 2B Domain Name Probable Starting Amino Acid Position Probable Ending Amino Acid Position Head 1 103 1A 104 138 L1 139 146 1B 147 247 L12 248 263 2A 264 282 L2 283 290 2B 291 411 Tail 412 466 Back to top

MONOCLONAL ANTIBODIES

Information last updated on 2008-08-27 10:02:41 Clone Name Species Reported Specificity Epitope Reference 17βG3 mouse GFAP, K1, K10, vimentin - Gown and Vogel, 1984 43βE8 mouse GFAP, vimentin - Gown and Vogel, 1984 4A4 mouse vimentin includes Ser(P)-55 Tsujimura et al, 1994 4G9 mouse vimentin - Varon et al, 1990 AMF-17b mouse vimentin - Isaacs et al, 1989 aV2 mouse vimentin - - LN-6 mouse vimentin - Stathopoulos et al, 1989 MO6 mouse vimentin includes Ser(P)-6 Inagaki et al, 1997 MO82 mouse vimentin includes Ser(P)-82 Ogawara et al, 1995 mVIM mouse vimentin - Broers et al, 1986 RBA1 rat vimentin - Pixley et al, 1984 RV201 mouse vimentin - Broers et al, 1986 RV202 mouse vimentin - - SMI26 mouse vimentin - - TM38 rat vimentin includes Ser(P)-38 Goto et al, 1998 TM50 mouse vimentin includes Ser(P)-50 Takai et al, 1996, Goto et al, 1998 TM71 rat vimentin includes Ser(P)-71 Goto et al, 1998 V9 mouse vimentin - Osborn et al, 1984, Bohn et al, 1992 VI-01 mouse vimentin - Dráberová et al, 1986 VI-10 mouse vimentin - Dráberová et al, 1999 VIM 3B4 mouse vimentin within 2A/L2/2B domains Bohn et al, 1992, Herrmann et al, 1989 XL-VIM-14.13 mouse vimentin - - YT33 mouse vimentin includes Ser(P)-33 Ogawara et al, 1995 Back to top

PROTEIN STRUCTURES
Information last updated on 2007-08-17 13:28:31 PDB ID View using Jmol 1GK4 View 1GK7 View Back to top

RELATED SEQUENCES AND MULTIPLE SEQUENCE ALIGNMENT

The following table shows the orthologous sequences in other organisms as indicated by NCBI HomoloGene ID 2538. Information last updated on 2007-08-17 12:21:54 Organism NCBI Gene ID mRNA Accession Protein Accession Taxonomy division Gallus gallus 420519 NM_001048076.1 NP_001041541.1 Vertebrates Rattus norvegicus 81818 NM_031140.1 NP_112402.1 Rodents Mus musculus 22352 NM_011701.3 NP_035831.2 Rodents Pan troglodytes 493952 NM_001009148.1 NP_001009148.1 Primates Canis familiaris 477991 XM_535175.2 XP_535175.2 Mammals Vertebrate ClustalW multiple sequence alignments Multiple sequence alignments were created using ClustalW for vertebrate sequences and the results available for viewing, download and visualization. Please use the analysis tools to include other sequences. Type of ClustalW alignment Download in FASTA format View file in FASTA format Nucleotide file view Protein file view Back to top

ASSOCIATED DISEASES
Information last updated on 2009-07-06 15:29:25 Click SEQUENCE VARIANTS to find individual mutations. Disease Name Disease Abbreviation OMIM Autosomal dominant cataract ADC #604219 Back to top

SEQUENCE VARIANTS

Note that a single record in the following table may represent multiple people with that particular variant who are in the same family. Click here to download an Excel spreadsheet of this data. Click here to open table in a new window (for ease of viewing and printing). Information last updated on 2009-07-06 15:29:25 * variant associated with disease as a risk factor rather than a causal factor. Note: Sequences are numbered according to latest reference sequence information. Discrepancies may exist with some publications. ID DNA Sequence Variant DNA Sequence Variant Type Protein Sequence Variant Protein Sequence Variant Type Domain Associated Disease Reference 13488 c.451G>A Substitution p.Glu151Lys Substitution 1B ADC Müller et al, 2009 Back to top