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This type forms intranuclear filaments, in contrast to all the other groups which assemble in the cytoplasm. The nuclear lamin intermediate filament proteins are thought to be the oldest type of intermediate filament in terms of evolution and share sequence characteristics with cytoplasmic filaments in invertebrates. There are three lamin genes in humans, encoding up to six proteins: (i) lamin A, lamin C1 and lamin C2 – three alternate splice products of the LMNA gene, (ii) lamin B1 (LMNB1), and (iii) lamins B2 and B3, encoded by the LMNB2 gene.
Click here for statistics of type V intermediate filament proteins. Last modified: August 27 2008 16:55:26. |
